The Ketogenic diet that produced a high level of ketone bodies through an excess of fat and lack of carbohydrates
The ketogenic diet is a mainstream dietary therapy that was developed to reproduce the success and remove the limitations of the non-mainstream use of fasting to treat epilepsy. Although popular in the 1920s and 1930s, it was largely abandoned in favour of new anticonvulsant drugs.
Most individuals with epilepsy can successfully control their seizures with medication. However, 25–30% fail to achieve such control despite trying several different drugs. For this group, and children in particular, the diet has once again found a role in epilepsy management.
In 1921, Rollin Turner Woodyatt reviewed the research on diet and diabetes. He reported that three water-soluble compounds, β-hydroxybutyrate, acetoacetate, and acetone (known collectively as ketone bodies), were produced by the liver in otherwise healthy people when they were starved or if they consumed a very low-carbohydrate, high-fat diet.
Dr Russell Morse Wilder, at the Mayo Clinic, built on this research and coined the term "ketogenic diet" to describe a diet that produced a high level of ketone bodies in the blood (ketonemia) through an excess of fat and lack of carbohydrates. Wilder hoped to obtain the benefits of fasting in a dietary therapy that could be maintained indefinitely. His trial on a few epilepsy patients in 1921 was the first use of the ketogenic diet as a treatment for epilepsy.
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